INCIDENCE AND RISK FACTORS OF DIABETIC RETINOPATHY AMONG PATIENTS WITH TYPE 2 DIABETES IN A COMMUNITY HOSPITAL, CENTRAL THAILAND

Authors

  • Patcharapol Wittayatechakul Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand
  • Paniti Hanyos Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand
  • Ram Rangsin Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand
  • Boonsub Sakboonyarat Department of Military and Community Medicine, Phramongkutklao College of Medicine, Bangkok, Thailand

DOI:

https://doi.org/10.55374/jseamed.v5i1.87

Keywords:

Diabetic retinopathy, Community hospital, Thailand, Incidence, Risk factors

Abstract

Background: Diabetic retinopathy (DR) is one of the ocular complications among patients with type 2 diabetes (T2D) in both developed and developing countries. At present, epidemiological data of DR and the risk factors among patients with T2D especially in Thai community hospitals have been limited.

Methods: A retrospective cohort study was conducted between January 1, 2013 and December 31, 2020 to determine the incidence and risk factors of DR among patients with T2D visiting Tha Wung Hospital, Lop Buri Province, central Thailand. DR was determined according to the International Classification of Diseases, Tenth Revision codes in E113 presented in medical records. Multivariate Cox regression analysis was performed to obtain the adjusted hazard ratios (HR) and 95% confidence interval (CI) of the factors related to DR.

Results: A total of 2007 patients with T2D were enrolled in the present study. During the study period, participants (5.3%) had a diagnosis of DR; the incidence rate was 0.9 per 100 person-years (95% CI; 0.7-1.1). The independent risk factors for DR included HbA1c ≥8% (adjusted hazard ratio (AHR) = 4.7, 95% CI; 2.5-8.7), urine albumin 3+ (AHR = 2.4, 95% CI; 1.1-5.3), urine albumin 4+ (AHR = 20.3, 95% CI; 2.7-150.9), and a longer distance between residential area (AHR= 1.3, 95% CI; 1.2-1.4).

Conclusion: Patients with T2D should be encouraged to reach their glycemic control indicated by HbA1c level. Additionally, effective health interventions should be conducted to contribute appropriate access to diabetic care for patients residing in remote areas.

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References

Du ZD, Hu LT, Zhao GQ, Ma Y, Zhou ZY, Jiang -T. Epidemiological characteristics and risk factors of diabetic retinopathy in type 2 diabetes mellitus in Shandong Peninsula of China. Inter J Ophthalmol 2011; 4: 202.

Giloyan A, Harutyunyan T, Petrosyan V. The prevalence of and major risk factors associated with diabetic retinopathy in Gegharkunik province of Armenia: cross-sectional study. BMC Ophthalmol 2015; 15: 1-7. DOI: https://doi.org/10.1186/s12886-015-0032-0

Willis JR, Doan QV, Gleeson M, Haskova Z, Ramulu P, Morse L, et al. Vision-related functional burden of diabetic retinopathy across severity levels in the United States. JAMA Ophthalmol 2017; 135: 926-32. DOI: https://doi.org/10.1001/jamaophthalmol.2017.2553

Song P, Yu J, Chan KY, Theodoratou E, Rudan I. Prevalence, risk factors and burden of diabetic retinopathy in China: a systematic review and meta-analysis. J Glob Health 2018; 8: 010803. DOI: https://doi.org/10.7189/jogh.08.010803

Li JQ, Welchowski T, Schmid M, Letow J, Wolpers C, Pascual-Camps I, et al. Prevalence, incidence and future projection of diabetic eye disease in Europe: a systematic review and meta-analysis. Eur J Epi 2020; 35: 11-23. DOI: https://doi.org/10.1007/s10654-019-00560-z

Henricsson M, Nystrom L, Blohme G, Ostman J, Kullberg C, Svensson M, et al. The incidence of retinopathy 10 years after diagnosis in young adult people with diabetes: results from the nationwide population based diabetes incidence study in Sweden (DISS). Diabetes Care 2003; 26: 349–54. DOI: https://doi.org/10.2337/diacare.26.2.349

Jin P, Peng J, Zou H, Li M, Li J, Xie SY, et al. The 5 year onset and regression of diabetic retinopathy in Chinese type 2 diabetes patients. PLoS One 2014; 9: e113359. DOI: https://doi.org/10.1371/journal.pone.0113359

Varma R, Choudhury F, Klein R, Chung J, Torres M, Azen SP, et al. Four year incidence and progression of diabetic retinopathy and macular edema: the Los Angeles Latino Eye Study. Am J Ophthalmol 2010; 149: 752–61. e1–3. DOI: https://doi.org/10.1016/j.ajo.2009.11.014

Khan R, Singh S, Surya J, Sharma T, Kulothunga V, Raman R. Age of onset of diabetes and its comparison with prevalence and risk factors for diabetic retinopathy in a rural population of India. Ophthalmic Res 2019; 61: 236-42. DOI: https://doi.org/10.1159/000496732

Euswas N, Phonnopparat N, Morasert K, Thakhampaeng P, Kaewsanit A, Mungthin M, et al. National trends in the prevalence of diabetic retinopathy among Thai patients with type 2 diabetes and its associated factors from 2014 to 2018. Plos One 2021; 16: e0245801. DOI: https://doi.org/10.1371/journal.pone.0245801

Reutrakul S, Deerochanawong C. Diabetes in Thailand: status and policy. Curr Diab Rep 2016; 16: 28. DOI: https://doi.org/10.1007/s11892-016-0725-7

Liu Y, Zupan NJ, Shiyanbola OO, Swearingen R, Carlson JN, Jacobson NA, et al. Factors influencing patient adherence with diabetic eye screening in rural communities: A qualitative study. PLoS One 2018; 13: e0206742. DOI: https://doi.org/10.1371/journal.pone.0206742

Happich M, Reitberger U, Breitscheidel L, Ulbig M, Watkins J. The economic burden of diabetic retinopathy in Germany in 2002. Graefe’s Arch Clin Exp Ophthalmol 2008; 246: 151-9. DOI: https://doi.org/10.1007/s00417-007-0573-x

Peavey JJ, D’Amico SL, Kim BY, Higgins ST, Friedman DS, Brady CJ. Impact of socio economic disadvantage and diabetic retinopathy severity on poor ophthalmic follow-up in a rural Vermont and New York population. Clin Ophthalmol 2020 ; 14: 2397-403. DOI: https://doi.org/10.2147/OPTH.S258270

Pradeepa R, Mohan V. Prevalence of type 2 diabetes and its complications in India and economic costs to the nation. Eur J Clin Nutr 2017; 71: 816-24. DOI: https://doi.org/10.1038/ejcn.2017.40

Association AD. Standards of medical care in diabetes-2013. Diabetes Care 2013; 36 (Suppl 1): S11–66. DOI: https://doi.org/10.2337/dc13-S011

Organization WH. ICD-10: international statistical classification of diseases and related health problems. 10th revision, 5th edition, 2016.

Cai J, Boulton M. The pathogenesis of diabetic retinopathy: old concepts and new questions. Eye 2002; 16: 242-60. DOI: https://doi.org/10.1038/sj.eye.6700133

Boelter MC, Gross JL, Canani LH, Costa LA, Lisboa HR, Três GS, et al. Proliferative diabetic retinopathy is associated with microalbuminuria in patients with type 2 diabetes. Braz J Med Biol Res 2006; 39: 1033-9. DOI: https://doi.org/10.1590/S0100-879X2006000800006

Lee MK, Han KD, Lee JH, Sohn SY, Hong OK, Jeong JS, et al. Normal-to-mildly increased albuminuria predicts the risk for diabetic retinopathy in patients with type 2 diabetes. Sci Rep 2017; 7: 1-8. DOI: https://doi.org/10.1038/s41598-017-11906-6

Rani PK, Raman R, Gupta A, Pal SS, Kulothungan V, Sharma T. Albuminuria and diabetic retinopathy in type 2 diabetes mellitus Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study (SN-DREAMS, report 12). Diabetol Metab Syndr 2011; 3: 1-8. DOI: https://doi.org/10.1186/1758-5996-3-9

Vujosevic S, Aldington SJ, Silva P, Hernández C, Scanlon P, Peto T, et al. Screening for diabetic retinopathy: new perspectives and challenges. Lancet Diabetes Endocrinol 2020; 8: 337-47. DOI: https://doi.org/10.1016/S2213-8587(19)30411-5

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Published

2021-06-21

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1.
Wittayatechakul P, Hanyos P, Rangsin R, Sakboonyarat B. INCIDENCE AND RISK FACTORS OF DIABETIC RETINOPATHY AMONG PATIENTS WITH TYPE 2 DIABETES IN A COMMUNITY HOSPITAL, CENTRAL THAILAND. J Southeast Asian Med Res [Internet]. 2021 Jun. 21 [cited 2024 Dec. 2];5(1):11-20. Available from: https://www.jseamed.org/index.php/jseamed/article/view/87

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