PREVALENCE OF ABNORMAL GLUCOSE METABOLISM AMONG THAI OVERWEIGHT AND OBESE CHILDERN AND ADOLESCENTS

  • Pacharin Mungklarat Division of Endocrinology, Department of Pediatrics, Phramongkutklao Hospial and Phramongkutklao College of Medicine
  • Anothai Juttuporn Division of Community, Occupational and Family Medicine, Faculty of Medicine, Burapha University
  • Wiphakorn Suphaphimon Division of Endocrinology, Department of Pediatrics, Phramongkutklao Hospial and Phramongkutklao College of Medicine
  • Warissara Sanor Division of Endocrinology, Department of Pediatrics, Phramongkutklao Hospial and Phramongkutklao College of Medicine
  • Chula Kooanantkul Kids Center, Vejthani Hospital
  • Nawaporn Numbenjapon Division of Endocrinology, Department of Pediatrics, Phramongkutklao Hospial and Phramongkutklao College of Medicine
  • Voraluck Phatarakijinirund Division of Endocrinology, Department of Pediatrics, Phramongkutklao Hospial and Phramongkutklao College of Medicine
Keywords: Impaired glucose tolerance, Imparied fasting glucose, Type 2 diabetes, Insulin resistance

Abstract

Background: The prevalence of childhood obesity is in creasingly worldwide. Abnormal glucose metabolism (ASM) including impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and type 2 diabetes (T2DM) is a common endocrine complication among overweight and obese children and adolescents. Few studies of AGM are available in Thailand.
Objectives: The study aimed to establish the prevalence of AGM and identify associated complications among overweight and obese children and adolescents.
Methods: Data of overweight and obese children and adolescents, aged 6 to 18 years, undergoing oral glucose tolerance test (OGTT) at phramongkutklao Hospital were reviewed retrospectively. Fasting blood sugar, Hemoglobin Ale (HbA1c). fasting insulin, triglyceride, high-density lipoprotein, low-density lipoprotein, aspartate transaminase and alanine aminotransferase were derived from fasting measurement. Homeostatic model assessment was calculated to represent the insulin resistance.
Result: A total of 204 children and adolescents (122 males) were included. Mean age was 12.1 ± 2.6 years and percent weight for height was 168.8 ± 25.4% The overall prevalence of AGM was 20.6%, 1 % had T2DM, 0.5% had IFG, 36% had IGT and 1.5% had combined IFG/IGT. Among the AGM, IGT was the most frequent subtype representing 92.8% (39/42 cases) but only 2 cases of T2DM were diagnosed in our study. The AGM group had significantly higher FPG (p=0.034), HbA1c (p=0.006) and cholesterol levels (p=0.043) than those of the nonabnormal glucose metabolism (NGM) group
Conclusion: Prevalences of AGM among overweight and obese children and adolescents were high. IGT was the most frequent group.

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Published
2019-12-01
How to Cite
1.
Mungklarat P, Juttuporn A, Suphaphimon W, Sanor W, Kooanantkul C, Numbenjapon N, Phatarakijinirund V. PREVALENCE OF ABNORMAL GLUCOSE METABOLISM AMONG THAI OVERWEIGHT AND OBESE CHILDERN AND ADOLESCENTS. J Southeast Asian Med Res [Internet]. 2019Dec.1 [cited 2022Jan.25];3(2):59-6. Available from: https://www.jseamed.org/index.php/jseamed/article/view/41
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Original Articles