ENDOMETRIAL GASTRIC-TYPE ADENOCARCINOMA ARISING IN THE BACKGROUND OF MUCINOUS METAPLASIA: A CASE REPORT
DOI:
https://doi.org/10.55374/jseamed.v9.246Keywords:
endometrial gastric-type adenocarcinoma, endometrial gastric (gastrointestinal)-type mucinous lesionAbstract
Endometrial gastric-type adenocarcinoma was recently included in the WHO Classification of Female Genital Tumors, 5th edition, as a very rare tumor. Some cases are linked to mucinous metaplasia, and histologic grade does not correlate with prognosis. Currently, there is no standard treatment available. This report describes a 70-year-old female patient who presented with leukorrhea. An endometrial biopsy revealed atypical mucinous glands and a positive result of p16, initially diagnosed as cervical adenocarcinoma. However, after a hysterectomy, a polypoid mass was identified in the endometrial cavity, leading to a revised diagnosis of endometrial gastric-type adenocarcinoma associated with mucinous metaplasia. Immunohistochemical staining showed positive results for CK20, CDX2, and MUC6 in the mucinous metaplasia region, whereas MUC6 was negative in the adenocarcinoma. The tumor was confined to the endometrium with no invasion or spread to lymph nodes. One-year postoperative follow-up showed no recurrence. This cancer is rare and has histological features that overlap with other tumors, underscoring the importance of differential diagnosis for accurate identification.
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